In this episode, Marc and Mo are joined by special guest Joseph Silburt, PhD (Data Scientist at OrthoEvidence) in an informative discussion on the issues related to artificial intelligence, machine-learning, and neural networks, with a specific focus on how these technologies can be applied to preoperative and perioperative planning. OrthoJOE Mailbag: feedback, comments, and suggestions from our audience can be sent to orthojoe@jbjs.org Links: • OrthoEvidence. An Overview of Machine Learning Applications for Conducting Systematic Reviews. OE Original. 2021;4(3):2. Available from: https://myorthoevidence.com/Blog/Show/118 • OrthoEvidence. Deep neural networks (machine learning) in healthcare. OE Original. 2019;2(6):1. Available from: https://myorthoevidence.com/Blog/Show/33 • OrthoEvidence. Rise of the Robots: The robot-assisted orthopaedic surgical Revolution. OE Insight. 2021; 2(1): 1. Available from: https://myorthoevidence.com/Download/51b28028-b6f9-4b2c-8ede-9209dbc642c8