In this episode, Marc and Mo are joined by special guest Gerard Slobogean, MD (Associate Professor and Director of Clinical Research, Department of Orthopaedics, University of Maryland School of Medicine) in an insightful conversation on the current issues and challenges related to the treatment of, and research into, open fractures. OrthoJOE Mailbag: feedback, comments, and suggestions from our audience can be sent to orthojoe@jbjs.org Links: • Chang Y, Bhandari M, Zhu KL, Mirza RD, Ren M, Kennedy SA, Negm A, Bhatnagar N, Naji FN, Milovanovic L, Fei Y, Agarwal A, Kamran R, Cho SM, Schandelmaier S, Wang L, Jin L, Hu S, Zhao Y, Lopes LC, Wang M, Petrisor B, Ristevski B, Siemieniuk RAC, Guyatt GH. Antibiotic Prophylaxis in the Management of Open Fractures: A Systematic Survey of Current Practice and Recommendations. JBJS Rev. 2019 Feb;7(2):e1. doi: 10.2106/JBJS.RVW.17.00197. PMID: 30724762. https://jbjs.org/reader.php?id=205004&rsuite_id=1938010&native=1&source=JBJS_Reviews/7/2/e1/abstract&topics=ta#info • Foote CJ, Tornetta P 3rd, Reito A, Al-Hourani K, Schenker M, Bosse M, Coles CP, Bozzo A, Furey A, Leighton R; GOLIATH Investigators. A Reevaluation of the Risk of Infection Based on Time to Debridement in Open Fractures: Results of the GOLIATH Meta-Analysis of Observational Studies and Limited Trial Data. J Bone Joint Surg Am. 2021 Feb 3;103(3):265-273. doi: 10.2106/JBJS.20.01103. Erratum in: J Bone Joint Surg Am. 2021 Mar 17;103(6):e25. PMID: 33298796. https://www.jbjs.org/reader.php?id=207441&rsuite_id=2681010&native=1&topics=ta&source=The_Journal_of_Bone_and_Joint_Surgery%2F103%2F3%2F265%2Ffulltext#content/contributor_reference_11 • PREP-IT Trial: https://www.prepittrial.com/ • Stennett CA, O'Hara NN, Sprague S, Petrisor B, Jeray KJ, Leekha S, Yimgang DP, Joshi M, O'Toole RV, Bhandari M, Slobogean GP; FLOW Investigators. Effect of Extended Prophylactic Antibiotic Duration in the Treatment of Open Fracture Wounds Differs by Level of Contamination. J Orthop Trauma. 2020 Mar;34(3):113-120. doi: 10.1097/BOT.0000000000001715. PMID: 32084088; PMCID: PMC8077225. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8077225/ Keywords: Orthopaedics, JBJS, OrthoEvidence, evidence-based medicine, open fracture, perioperative care, soft-tissue care, topical antiobiotics, IV antibotics, antibiotic duration, wound contamination, fracture classification, wound irrigation, wound debridement, surgical site infection, timing of treatment, factorial design, mentorship, FLOW investigators, GOLIATH investigators, innovation, laser angiography, SPY system, flap coverage, NIAMS, OTA, Major Extremity Trauma Research Consortium (METRC)