In this episode, Marc and Mo are joined by special guest Zain Chagla, MD (Associate Professor of Medicine and Director of Infection Control at McMaster University and St. Joseph’s Hospital) in a timely discussion of the current landscape and evolving strategies related to the ongoing COVID-19 pandemic, with a focus on the Omicron variant as well as the interface between social media and science. OrthoJOE Mailbag: feedback, comments, and suggestions from our audience can be sent to orthojoe@jbjs.org Links: • Vannabouathong C, Devji T, Ekhtiari S, Chang Y, Phillips SA, Zhu M, Chagla Z, Main C, Bhandari M. Novel Coronavirus COVID-19: Current Evidence and Evolving Strategies. J Bone Joint Surg Am. 2020 May 6;102(9):734-744. doi: 10.2106/JBJS.20.00396. https://jbjs.org/reader.php?id=206110&rsuite_id=2387011&native=1&source=The_Journal_of_Bone_and_Joint_Surgery/102/9/734/fulltext&topics=if%2Boe#info • López-Medina E, López P, Hurtado IC, Dávalos DM, Ramirez O, Martínez E, Díazgranados JA, Oñate JM, Chavarriaga H, Herrera S, Parra B, Libreros G, Jaramillo R, Avendaño AC, Toro DF, Torres M, Lesmes MC, Rios CA, Caicedo I. Effect of Ivermectin on Time to Resolution of Symptoms Among Adults With Mild COVID-19: A Randomized Clinical Trial. JAMA. 2021 Apr 13;325(14):1426-1435. doi: 10.1001/jama.2021.3071. https://pubmed.ncbi.nlm.nih.gov/33662102/ Keywords: Orthopaedics, JBJS, OrthoEvidence, COVID, pandemic, variant, Omicron, Alpha, Beta, Delta, immunity, transmissibility, minimal infective dose, immunoevasion, reinfection, upper respiratory tract infection, vaccination rates, booster, antibody levels, MRNA, contact tracing, hospitalization, death, mutated spike proteins, population health, ICU, endemic, cross neutralization, long COVID, persistent symptoms, psychiatric symptoms, end-organ dysfunction, lung fibrosis, chronic fatigue syndrome, chronic inflammation, rehabilitative services, psychiatric services, post-infectious complications, holistic multidisciplinary solutions, oral antivirals, ICU, vaccine, immune response, viral reservoirs, tropism, monoclonal antibodies, clinical trial, recovery, inflammatory cascade, therapeutics, Ivermectin, social media, misinformation