In this episode, Marc and Mo discuss 2 recent JBJS and OE articles that caught their eye. The first part of the discussion focuses on a large RCT evaluating the effect of supplemental perioperative oxygen on SSI among adults with lower-extremity fractures, and the second part focuses on a systematic review on the use of medical ozone versus hyaluronic acid for knee OA. Links: • Major Extremity Trauma Research Consortium (METRC). Effect of Supplemental Perioperative Oxygen on SSI Among Adults with Lower-Extremity Fractures at Increased Risk for Infection: A Randomized Clinical Trial. J Bone Joint Surg Am. 2022 Jul 20;104(14):1236-1243. doi: 10.2106/JBJS.21.01317. Epub 2022 May 11. PMID: 35775284. https://bit.ly/3Q2hPvF • OrthoEvidence. Intra-Articular Injection of Medical Ozone Versus Hyaluronic Acid for Knee Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. OE Original. 2022;5(5):3. Available from: https://myorthoevidence.com/Blog/Show/183 Subspecialties: • Infection • Knee • Orthopaedic Essentials • Trauma Keywords: Orthopaedics, JBJS, OrthoEvidence, OE, Major Extremity Trauma Research Consortium, METRC, oxygen, SSI, fracture, infection, RCT, medical ozone, hyaluronic acid, HA, knee OA, FiO2, tibial plateau fracture, tibial pilon fracture, calcaneal fracture, perioperative care, guidelines, systematic review, meta-analysis, blinding, silos, collaboration, placebo control, embolism, patient enrollment, patient consent