In this episode, Marc and Mo are joined by Special Guests Daniel Berry, Hilal Maradit Kremers, and David Lewallen (all from the Mayo Clinic) in a discussion on a 2021 workshop and upcoming JBJS supplement focusing on the power and potential of large databases; the weaknesses and risks of analyses using these databases; the methods, specific attributes, and best uses of the most commonly used databases; and the optimum use of administrative datasets and registries in orthopaedic research. Links: • Large Database and Registry Research in Joint Arthroplasty and Orthopaedics (upcoming JBJS Supplement) https://jbjs.org/reader.php?rsuite_id=3471741&native=1 Subspecialties: • Hip • Knee • Orthopaedic Essentials Keywords: Orthopaedics, JBJS, OrthoEvidence, NIH/NIAMS P30 center grant, OREF, joint arthroplasty, database, registry, NLP, natural language processing, AI, artificial intelligence, data accessibility, causality, technology, robotics, AJRR, data linkage, nested trial, big data, real-world evidence.