In this episode, Mo and Marc discuss are joined by special guest Jason Busse (Professor, Department of Anesthesia, McMaster University; Canada Research Chair) to discuss his recent BMJ systematic review and network meta-analysis on chronic non-cancer spine pain, with an emphasis on the relative benefits of interventional vs. sham procedures. Links: • Wang X, Martin G, Sadeghirad B, Chang Y, Florez ID, Couban RJ, Mehrabi F, Crandon HN, Esfahani MA, Sivananthan L, Sengupta N, Kum E, Rathod P, Yao L, Morsi RZ, Genevay S, Buckley N, Guyatt GH, Rampersaud YR, Standaert CJ, Agoritsas T, Busse JW. Common interventional procedures for chronic non-cancer spine pain: a systematic review and network meta-analysis of randomised trials. BMJ. 2025 Feb 19;388:e079971. doi: 10.1136/bmj-2024-079971. PMID: 39971346. https://bit.ly/3FR2Jth Subspecialties: • Orthopaedic Essentials • Pain Management • Spine Keywords: Orthopaedics, orthopedics, JBJS, OrthoEvidence, cancer, pain, spine, axial, radicular, interventional procedures, clinical benefit, sham procedures, RCT, CPG, clinical practice guidelines, injection, steroids, joint radiofrequency ablation, anesthetic, nerve block, acute pain, chronic pain, network meta-analysis, direct evidence, indirect evidence, treatment effect, precision, referred pain, placebo, complications, subgroup analysis