In this episode, Mo and Marc are joined by special guests Karim Ramji (bariatric surgeon, entrepreneur, and researcher at McMaster University) and Jamie Le (internal medicine and obesity specialist at HOW Clinics) in a discussion on GLP-1 agonists and their role in orthopaedics, particularly for weight loss and surgical outcomes. Links: • Kim BI, LaValva SM, Parks ML, Sculco PK, Della Valle AG, Lee GC. Glucagon-Like Peptide-1 Receptor Agonists Decrease Medical and Surgical Complications in Morbidly Obese Patients Undergoing Primary TKA. J Bone Joint Surg Am. 2025 Feb 19;107(4):348-355. doi: 10.2106/JBJS.24.00468. Epub 2024 Dec 24. PMID: 39719003. https://bit.ly/4jvCvdX Subspecialties: • Orthopaedic Essentials Keywords: Orthopaedics, orthopedics, JBJS, OrthoEvidence, obesity, weight loss, outcomes, quality of life, bariatric surgery, GLP-1, proteins, diabetes, Ozempic, appetite, hunger, craving, satiety, CNS, weight management, behavioral change, hind gut theory, distal gut theory, biochemistry, sick fat disease, fat mass disease, side effects, GI, pancreatitis, calorie deficit, plateau, muscle mass, database study, PJI, PE, VTE, readmissions, sleep apnea, hypertension, glucose profile, infection profile, return to work, weight regain, long-term impact, inflammation, cytokines, lifestyle modifications, AI, robotics
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