In this episode, Mo and Marc are joined by special guests Drs. Sheila Ann Sprague and Sameer Parpia (Associate Professors at McMaster University and Senior Editors for Statistics and Methodology at JBJS) in a discussion on the importance of methodological rigor when designing clinical trials. Subspecialties: • Orthopaedic Essentials Keywords: Orthopaedics, orthopedics, JBJS, OE, statistics, methodology, biostatistics, health research methodology, RCT, scoping reviews, meta-analyses, systematic reviews, pilot studies, patient recruitment, event rates, secondary analyses, clinical equipoise, PICO question, Bayesian analysis, methodological rigor, prior knowledge, bias, sample size, sensitivity, frequentist statistics, biostatistics, research question, study design, objectivity, instructions for authors, CONSORT statement, clarity, transparency, limitations, randomization