In this episode, Mo and Marc are joined by special guest Michelle Ghert, MD (Professor of Orthopaedics and University of Maryland School of Medicine and Executive Editor, JBJS) in a discussion on the challenges and benefits of performing large, multinational RCTs in orthopaedic oncology, with an emphasis on the development of global networks and the challenges and opportunities facing the research community in the future. Subspecialties: • Orthopaedic Essentials • Oncology Keywords: Orthopaedics, orthopedics, JBJS, OE, oncology, clinical trials, RCTs, strategy, international trials, international collaboration, research culture, clinical research, basic science, multicenter trials, globalization, resources, low-resource environments, global research, South America, Europe, Southeast Asia, North America, India, South Africa, Brazil, evidence-based medicine, mentorship, SPRINT trial, AI, LLM, challenges, opportunities, technology, global networks, data quality, monetary incentives, guidance, PARITY