In this episode, Marc and Mo discuss a number of intriguing questions related to the use of orthobiologics in orthopaedics: How do we set standards for novel biologics? How do we decide what works and what doesn’t? What filter should be used to determine which studies get published? Ultimately, we need to know how these materials are prepared and what is actually in them before we can evaluate their effect on patients. Answering these questions is essential work in order for us to make advances in this field. OrthoJOE Mailbag: feedback, comments, and suggestions from our audience can be sent to orthojoe@jbjs.org Links: • Siddiqua A, Bhandari M. Platelet Rich Plasma and Stem Cell Therapy: Setting Standards and Evidence. OrthoEvidence. Article No. 97. August 21, 2021. https://myorthoevidence.com/Insight/Show/97 • Murray IR, Safran MR, LaPrade RF. Biologics in orthopaedics. Bone & Joint 360. 2018;7(6):2-8. https://online.boneandjoint.org.uk/action/showCitFormats?doi=10.1302%2F2048-0105.76.360648 • Cole BJ, Gilat R, DiFiori J, Rodeo SA, Bedi A. The 2020 NBA Orthobiologics Consensus Statement. Orthop J Sports Med. 2021 May 6;9(5):23259671211002296. doi: 10.1177/23259671211002296. PMID: 34017878; PMCID: PMC8114275. https://pubmed.ncbi.nlm.nih.gov/34017878/ • Lamplot JD, Rodeo SA, Brophy RH. A Practical Guide for the Current Use of Biologic Therapies in Sports Medicine. Am J Sports Med. 2020 Feb;48(2):488-503. doi: 10.1177/0363546519836090. Epub 2019 Apr 30. PMID: 31038990. https://pubmed.ncbi.nlm.nih.gov/31038990/ • Bauer TW. Stem Cell Therapy for Knee Pain-What Exactly Are We Injecting, and Why? J Bone Joint Surg Am. 2016 Sep 21;98(18):1509-10. doi: 10.2106/JBJS.16.00872. PMID: 27655977. https://bit.ly/3Bc2TUz