In this episode, Marc and Mo provide their predictions for scholarly publication trends in 2022, including the use of algorithms to solve complex problems, innovations in rehabilitative strategies, “side hustles” for researchers and surgeons, the generational impact in orthopaedic education, the impact of patient mental health and personality on the process of care, a greater focus on “what really matters” in life, and the musculoskeletal implications of Long COVID. OrthoJOE Mailbag: feedback, comments, and suggestions from our audience can be sent to orthojoe@jbjs.org Links: • Malizos KN. Long COVID-19: A New Challenge to Public Health. J Bone Joint Surg. 2022 Feb 2. 10.2106/JBJS.21.02176 [AMH: Add hyperlink when known] Keywords: Orthopaedics, JBJS, OrthoEvidence, algorithms, wearables, database, AI, machine learning, rehabilitative strategies, polywork, side hustles, entrepreneurship, mental health, personality, somatic preoccupation, soft skills, passion, arts and humanities, Long COVID