In this episode, Marc and Mo discuss 3 recent articles that caught their eye. The first part of the discussion focuses on the importance of blinded assessments of outcomes in clinical trials, and the second part focuses on the use of tranexamic acid in patients with hip fractures. • Metcalfe A, Parsons H, Parsons N, Brown J, Fox J, Gemperlé Mannion E, Haque A, Hutchinson C, Kearney R, Khan I, Lawrence T, Mason J, Stallard N, Underwood M, Drew S; START:REACTS team. Subacromial balloon spacer for irreparable rotator cuff tears of the shoulder (START:REACTS): a group-sequential, double-blind, multicentre randomised controlled trial. Lancet. 2022 May 21;399(10339):1954-1963. doi: 10.1016/S0140-6736(22)00652-3. Epub 2022 Apr 21. PMID: 35461618. https://bit.ly/3P62z0I • Verma N, Srikumaran U, Roden CM, Rogusky EJ, Lapner P, Neill H, Abboud JA; SPACE GROUP. InSpace Implant Compared with Partial Repair for the Treatment of Full-Thickness Massive Rotator Cuff Tears: A Multicenter, Single-Blinded, Randomized Controlled Trial. J Bone Joint Surg Am. 2022 Apr 22. doi: 10.2106/JBJS.21.00667. Epub ahead of print. PMID: 35777921. https://bit.ly/3cBTmz6 • Porter SB, Spaulding AC, Duncan CM, Wilke BK, Pagnano MW, Abdel MP. Tranexamic Acid Was Not Associated with Increased Complications in High-Risk Patients with Intertrochanteric Fracture. J Bone Joint Surg Am. 2022 Jul 6;104(13):1138-1147. doi: 10.2106/JBJS.21.01389. Epub 2022 Apr 29. PMID: 35775092. https://bit.ly/3AHrhjT • POISE Study Group, Devereaux PJ, Yang H, Yusuf S, Guyatt G, Leslie K, Villar JC, Xavier D, Chrolavicius S, Greenspan L, Pogue J, Pais P, Liu L, Xu S, Málaga G, Avezum A, Chan M, Montori VM, Jacka M, Choi P. Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomised controlled trial. Lancet. 2008 May 31;371(9627):1839-47. doi: 10.1016/S0140-6736(08)60601-7. Epub 2008 May 12. PMID: 18479744. https://pubmed.ncbi.nlm.nih.gov/18479744/ Keywords: Orthopaedics, JBJS, OrthoEvidence, Lancet, blinding, masking, rotator cuff tear, balloon spacer, TXA, complications, intertrochanteric fracture, bleeding risk Subspecialties: • Shoulder • Trauma • Hip • Orthopaedic Essentials