In this episode, Mo and Marc are joined by special guest Jason Busse (Professor in the Department of Anesthesia at McMaster University, Director of the National Pain Centre, and Associate Director of the Michael G. DeGroote Centre for Medicinal Cannabis Research), in a discussion on research into the relative effectiveness and harms associated with various types of opioids, cannabinoids, and psychedelics in the treatment of chronic pain. Links: • Noori A, Sadeghirad B, Wang L, Siemieniuk RAC, Shokoohi M, Kum E, Jeddi M, Montoya L, Hong PJ, Zhou E, Couban RJ, Juurlink DN, Thabane L, Bhandari M, Guyatt GH, Busse JW. Comparative benefits and harms of individual opioids for chronic non-cancer pain: a systematic review and network meta-analysis of randomised trials. Br J Anaesth. 2022 Sep;129(3):394-406. doi: 10.1016/j.bja.2022.05.031. Epub 2022 Jul 9. PMID: 35817616. https://bit.ly/3KOtVat • Kane RL, Bershadsky B, Rockwood T, Saleh K, Islam NC. Visual Analog Scale pain reporting was standardized. J Clin Epidemiol. 2005 Jun;58(6):618-23. doi: 10.1016/j.jclinepi.2004.11.017. PMID: 15878476. https://bit.ly/3BrSIyd • Busse JW, Craigie S, Juurlink DN, Buckley DN, Wang L, Couban RJ, Agoritsas T, Akl EA, Carrasco-Labra A, Cooper L, Cull C, da Costa BR, Frank JW, Grant G, Iorio A, Persaud N, Stern S, Tugwell P, Vandvik PO, Guyatt GH. Guideline for opioid therapy and chronic noncancer pain. CMAJ. 2017 May 8;189(18):E659-E666. doi: 10.1503/cmaj.170363. PMID: 28483845; PMCID: PMC5422149. https://bit.ly/3QhqY3f Subspecialties: • Basic Science • Education and Training • Ethics • Foot & Ankle • Hand & Wrist • Hip • Knee • Oncology • Orthopaedic Essentials • Pain Management • Rehabilitation • Pediatrics • Spine • Shoulder • Elbow • Sports Medicine • Trauma Keywords: Orthopaedics, JBJS, OrthoEvidence, OE, pain, opioids, cannabinoids, psychedelics, magic mushrooms, psilocybin, systematic review, network meta-analysis, nerve-sparing, VAS, visual analog scale, sleep quality, function, codeine, tramadol, oxycodone, fentanyl, placebo, statistical modeling, surface under the cumulative ranking curve, SUCRA, minimally contextualized approach, GI harms, gastrointestinal harms, pain interpretation, patient-related factors, opioid epidemic, tapering