In this episode, Mo and Marc are joined by special guest Moin Khan, MD (Associate Professor of Orthopaedic Surgery, McMaster University) in a discussion focusing on the methodological challenges of PRP research. Links: • Bensa A, Previtali D, Sangiorgio A, Boffa A, Salerno M, Filardo G. PRP Injections for the Treatment of Knee Osteoarthritis: The Improvement Is Clinically Significant and Influenced by Platelet Concentration: A Meta-analysis of Randomized Controlled Trials. Am J Sports Med. 2025 Jan 3:3635465241246524. doi: 10.1177/03635465241246524. Epub ahead of print. PMID: 39751394. https://bit.ly/4jtUWRg • Chahla J, Cinque ME, Piuzzi NS, Mannava S, Geeslin AG, Murray IR, Dornan GJ, Muschler GF, LaPrade RF. A Call for Standardization in Platelet-Rich Plasma Preparation Protocols and Composition Reporting: A Systematic Review of the Clinical Orthopaedic Literature. J Bone Joint Surg Am. 2017 Oct 18;99(20):1769-1779. doi: 10.2106/JBJS.16.01374. PMID: 29040132. https://bit.ly/4hrndpX Subspecialties: • Foot & Ankle • Hand & Wrist • Hip • Knee • Orthopaedic Essentials • Spine • Shoulder • Elbow • Sports Medicine • Trauma Keywords: Orthopaedics, orthopedics, JBJS, OrthoEvidence, OA, PRP, platelet-rich-plasma, knee, osteoarthritis, placebo, platelet-rich plasma, systematic review, meta-analysis, shoulder, leukocyte-poor, leukocyte-rich, control, orthobiologics, regenerative medicine, stem cells, exosomes, signal, noise, effect, PRP protocols, PRP composition, heterogeneity, FDA, topical, oral, paste, injectable, impact, HA, hyaluronic acid, needle, anti-inflammatory, blood components, patient psyche, treatment effect, blinding, bias, effect size, cortisone, sample size, methodology, outcomes, cell concentration