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OrthoJOE

106. The Many Challenges of PRP Research, with special guest Moin Khan, MD

In this episode, Mo and Marc are joined by special guest Moin Khan, MD (Associate Professor of Orthopaedic Surgery, McMaster University) in a discussion focusing on the methodological challenges of PRP research. Links: • Bensa A, Previtali D, Sangiorgio A, Boffa A, Salerno M, Filardo G. PRP Injections for the Treatment of Knee Osteoarthritis: The Improvement Is Clinically Significant and Influenced by Platelet Concentration: A Meta-analysis of Randomized Controlled Trials. Am J Sports Med. 2025 Jan 3:3635465241246524. doi: 10.1177/03635465241246524. Epub ahead of print. PMID: 39751394. https://bit.ly/4jtUWRg • Chahla J, Cinque ME, Piuzzi NS, Mannava S, Geeslin AG, Murray IR, Dornan GJ, Muschler GF, LaPrade RF. A Call for Standardization in Platelet-Rich Plasma Preparation Protocols and Composition Reporting: A Systematic Review of the Clinical Orthopaedic Literature. J Bone Joint Surg Am. 2017 Oct 18;99(20):1769-1779. doi: 10.2106/JBJS.16.01374. PMID: 29040132. https://bit.ly/4hrndpX Subspecialties: • Foot & Ankle • Hand & Wrist • Hip • Knee • Orthopaedic Essentials • Spine • Shoulder • Elbow • Sports Medicine • Trauma Keywords: Orthopaedics, orthopedics, JBJS, OrthoEvidence, OA, PRP, platelet-rich-plasma, knee, osteoarthritis, placebo, platelet-rich plasma, systematic review, meta-analysis, shoulder, leukocyte-poor, leukocyte-rich, control, orthobiologics, regenerative medicine, stem cells, exosomes, signal, noise, effect, PRP protocols, PRP composition, heterogeneity, FDA, topical, oral, paste, injectable, impact, HA, hyaluronic acid, needle, anti-inflammatory, blood components, patient psyche, treatment effect, blinding, bias, effect size, cortisone, sample size, methodology, outcomes, cell concentration

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