In this episode, Mo and Marc discuss best practices and common challenges in planning secondary analyses from clinical trials, including data collection and analysis protocols, the distinction between primary and secondary questions, hypothesis-driven design, statistical power, process transparency, and dissemination strategies. Subspecialties: • Trauma • Orthopaedic Essentials Links: • Shu HT, Hoveidaei AH, Reider LM, Vallier HA, Quinnan S, Gary JL, Carroll EA, Carlini AR, Higgins TF, Bosse MJ, Shafiq B, Tornetta P 3rd, O'Toole RV, Castillo RC; METRC (Major Extremity Trauma Research Consortium). Pain Outcomes Following Modern External Ring Fixation Compared with Internal Fixation for Severe Open Tibial Fractures: A Secondary Analysis of a Prospective Randomized Trial (FIXIT). J Bone Joint Surg Am. 2026 May 6;108(9):649-657. doi: 10.2106/JBJS.25.00964. Epub 2026 Mar 18. PMID: 41849563. https://bit.ly/4fl6E12 Keywords: Orthopaedics, orthopedics, JBJS, OE, EBO, Ravi Shankar, AOA, METRC, FIXIT, DOD, pain, modern ring fixation, internal fixation, pin-site infection, secondary analysis, LEAP, open tibial fractures, RCT, post hoc analysis, clinicaltrials.gov, cherry-picking, trial registration, statistical fishing expeditions, statistical power, documentation, sample size, SPRINT, FAITH, FLOW, unlocked database, publication committee, transparency, apriori power analysis, strategies for dissemination, impact, compendium, supplement, budgeting, publication costs, PARITY, overall message, storyline, collaboratives, open access