In this episode, Marc and Mo discuss several recent JBJS and OE articles that caught their eye. The first part of the discussion focuses on selected highlights from the recent meeting of the OTA (specifically, anti-sepsis approaches in open fracture management), and the second part focuses on the recently published JBJS Supplement on the use of large databases in orthopaedic research. Links: • OrthoEvidence. OTA 2022: Key Findings from This Year’s RCTs and Meta-Analyses. OE Insights. 2022. https://myorthoevidence.com/Insight/Show/147 • JBJS Supplement on Large Database and Registry Research in Joint Arthroplasty and Orthopaedics. https://jbjs.org/collection.php?id=22 • Khosravi B, Rouzrokh P, Erickson BJ. Getting More Out of Large Databases and EHRs with Natural Language Processing and Artificial Intelligence: The Future Is Here. J Bone Joint Surg Am. 2022 Oct 19;104(Suppl 3):51-55. doi: 10.2106/JBJS.22.00567. Epub 2022 Oct 19. PMID: 36260045. https://bit.ly/3suFxqK • Swiontkowski MF, Callaghan JJ, Lewallen DG, Berry DJ. Large Database and Registry Research in Joint Arthroplasty and Orthopaedics. J Bone Joint Surg Am. 2022 Oct 19;104(20):1775-1777. doi: 10.2106/JBJS.22.00405. Epub 2022 Oct 19. PMID: 36260046. https://bit.ly/3TFAQ9o Subspecialties: • Ethics • Hip • Infection • Knee • Orthopaedic Essentials • Trauma Keywords: Orthopaedics, JBJS, OrthoEvidence, trauma, anti-sepsis, chlorhexidine, basic science, ACE report, Lancet, aqueous solutions, antiseptic, povidone-iodine, alcohol, wound irrigation, saline, soap, FLOW trial, PREP-IT, complications, femoral neck fracture, FAITH, case series, unsolved fracture, NLP, natural language processing