Marc and Mo discuss amputation surgery in diabetic patients, with a focus on the risk factors for failure following amputation, the challenges to performing RCTs in this area, and the need for multidisciplinary consortia focused on this topic. Links: • Ron I, Kyin C, Peskin B, Ghrayeb N, Norman D, Ben-Kiki T, Shapira J. Risk Factors for a Failed Transmetatarsal Amputation in Patients with Diabetes. J Bone Joint Surg Am. 2023 May 3;105(9):651-658. doi: 10.2106/JBJS.22.00718. Epub 2023 Mar 21. PMID: 36943915. https://bit.ly/3o72Et0 • OrthoEvidence. Fenofibrate produces a reduction in amputation events in type II diabetics. ACE Report. 2013;2(4):82. Available from: https://myorthoevidence.com/AceReport/Report/333 Subspecialties: • Ethics • Orthopaedic Essentials • Rehabilitation Keywords: Orthopaedics, orthopedics, JBJS, OrthoEvidence, OE, LEAP trial, amputation, limb salvage, RCT, diabetes, glycemic control, lipid profile, triglycerides, lipid-lowering medications, kidney disease, TMA, transmetatarsal amputation, dialysis, CCI, Charlson Comorbidity Index, wound dehiscence, fenofibrate, hypertriglyceridemia, prognosis, prosthetist, foot ulceration, eye disease