In this episode, Marc and Mo are joined by special guest Matthew Costa, Professor of Orthopaedic Trauma Surgery at University of Oxford, in a discussion network trials in the UK and their impact on front-line patient care as well as the importance of patient involvement when setting research priorities. Links: • James Lind Alliance: https://www.jla.nihr.ac.uk/ • Fernandez MA, Achten J, Parsons N, Griffin XL, Png ME, Gould J, McGibbon A, Costa ML; WHiTE 5 Investigators. Cemented or Uncemented Hemiarthroplasty for Intracapsular Hip Fracture. N Engl J Med. 2022 Feb 10;386(6):521-530. doi: 10.1056/NEJMoa2108337. PMID: 35139272. https://www.nejm.org/doi/pdf/10.1056/NEJMoa2108337 • Costa ML, Achten J, Marian IR, Dutton SJ, Lamb SE, Ollivere B, Maredza M, Petrou S, Kearney RS; UKSTAR trial collaborators. Plaster cast versus functional brace for non-surgical treatment of Achilles tendon rupture (UKSTAR): a multicentre randomised controlled trial and economic evaluation. Lancet. 2020 Feb 8;395(10222):441-448. doi: 10.1016/S0140-6736(19)32942-3. PMID: 32035553; PMCID: PMC7016510. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)32942-3/fulltext Subspecialties: • Orthopaedic Essentials • Trauma Keywords: Orthopaedics, orthopedics, JBJS, OrthoEvidence, NHS, NIHR, National Institute for Health and Care Research, discovery science, front-line patient care, collaboration, James Lind Alliance, patient involvement, patient engagement, mentorship