In this episode, Marc and Mo discuss the value of basic science as a clinical research tool, with a specific focus on a recent JBJS study evaluating in vivo joint loads during swimming in patients with hip and knee prostheses. Links: • Schemitsch EH, Kowalski MJ, Swiontkowski MF, Senft D. Cortical bone blood flow in reamed and unreamed locked intramedullary nailing: a fractured tibia model in sheep. J Orthop Trauma. 1994 Oct;8(5):373-82. doi: 10.1097/00005131-199410000-00002. PMID: 7996319. • Zhou S, Bender A, Kutzner I, Dymke J, Maleitzke T, Perka C, Duda GN, Winkler T, Damm P. Loading of the Hip and Knee During Swimming: An in Vivo Load Study. J Bone Joint Surg Am. 2023 Dec 20;105(24):1962-1971. doi: 10.2106/JBJS.23.00218. Epub 2023 Oct 23. PMID: 38079507. https://bit.ly/3RVsSux • Xiong GX, Kang JR, Sharma J, et al. Biomechanically superior treatments do not translate into improved outcomes in randomized controlled trials. European Journal of Orthopaedic Surgery & Traumatology : Orthopedie Traumatologie. 2022 Jul;32(5):933-938. DOI: 10.1007/s00590-021-03051-8. PMID: 34176011. Subspecialties: • Basic Science Keywords: Orthopaedics, orthopedics, JBJS, OrthoEvidence, basic science, swimming, reamed tibial nails, unreamed tibial nails, sheep model, SPRINT study, joint contact forces, biomechanical studies, preclinical studies, hypothesis generation, changing practice, bias, blinding