In this episode, Marc and Mo are joined by special guests Dr. Sheila Sprague (Research Director and Associate Professor PT at McMaster University) and Dr. Gerard Slobogean (Director of Clinical Research for the Department of Orthopaedics at the University of Maryland School of Medicine) in a discussion of the landmark PREPARE trial, focusing on skin antisepsis before fracture surgery. Links: • PREP-IT Investigators. Skin Antisepsis before Surgical Fixation of Extremity Fractures. N Engl J Med. 2024 Feb 1;390(5):409-420. doi: 10.1056/NEJMoa2307679. PMID: 38294973. https://bit.ly/4c13uLZ Subspecialties: • Infection • Trauma Keywords: Orthopaedics, orthopedics, JBJS, OrthoEvidence, antisepsis, ChloraPrep, chlorhexidine, alcohol, povacrylex, iodine, DuraPrep, SSI, surgical site infection, open fracture, closed fracture, reoperation, methodology, subgroup analysis, cluster crossover randomized design, SPRINT trial, compliance, risk assessment, aspirin, beta-blockers, standard of care, behavioral economics, patient partners, stepped wedge design, AI, artificial intelligence, knowledge translation plan, KT plan, funding, flora, perseverence