In this episode, Mo and Marc are joined by special guests Bheeshma Ravi, MD, PhD, FRCSC (Associate Professor, University of Toronto), and Raman Mundi, MD, MSc, FRCSC (Assistant Professor, University of Toronto), in a discussion of their recent large database study (n > 175,000), which showed that PJI within 1 year after surgery was associated with over a fivefold increased risk of mortality within 10 years. Links: • Mundi R, Pincus D, Schemitsch E, Ekhtiari S, Paterson JM, Chaudhry H, Leis JA, Redelmeier DA, Ravi B. Association Between Periprosthetic Joint Infection and Mortality Following Primary Total Hip Arthroplasty. J Bone Joint Surg Am. 2024 Sep 4;106(17):1546-1552. doi: 10.2106/JBJS.23.01160. Epub 2024 May 9. PMID: 38723055. https://bit.ly/4ef5Rvm • JBJS Article Collection: Large Database and Registry Research in Joint Arthroplasty and Orthopaedics: https://www.jbjs.org/collection.php?id=22 Subspecialties: • Hip • Infection • Knee • Orthopaedic Essentials Keywords: Orthopaedics, orthopedics, JBJS, OrthoEvidence, prevention, diagnosis, treatment, infection, TJA, THA, TKA, knee, hip, mortality, complications, comorbidity, functional decline, population-based study, database study, confounding, statistical methods, regression analysis, matching, validation, observational trial, RCT, antibiotics, perioperative, colonization, surgeon volume, revision, risk, single-stage, two-stage